CARE Perspectives on ASH 2016

Highlights from ASH 2016

Members of the CARE Hematology Faculty recently attended the ASH 2016 conference held in San Diego, California from December 3rd-6th, 2016. CARE Faculty Chair, Dr. John Kuruvilla also hosted the 11th annual CARE at ASH Resident and Trainee Education Meeting in conjunction with the conference. This was a highly successful meeting with participation from over 120 hematology professionals (residents and faculty specialists). For more information in this event and for additional CARE at ASH resources please visit www.CAREeducation.ca. 

This issue of CARE Perspectives from ASH 2016 provides a summary of the most exciting and relevant stories presented at the conference. Abstract content is augmented with additional perspectives from Dr. John Kuruvilla as well as select CARE at ASH presenting Faculty, including Drs. Diego Villa (CLL), Laurie Sehn (NHL), Andre Schuh (Leukemia), and Kevin Song (MM).

The content that follows is written in the language in which it was presented and is adapted from the abstracts presented during the ASH 2016 meeting. Of note, some abstracts have been updated to reflect the data presented during the oral plenary sessions at ASH.

CARE Perspectives on CHC 2016

The 6th annual Canadian Hematology Conference (CHC 2016) successfully took place on September 23rd-24th in Toronto, Ontario. We were pleased to welcome a dynamic faculty of Canadian and International KOL’s who provided cutting-edge presentations on a variety of hematological malignancies and benign disorders. 

This conference is run every year with the goal of bringing hematology professionals together to learn, network, and share experiences relating to the management of hematological disorders in Canada. This year was our largest conference yet, with over 160 academic and community specialists, residents, nurses and pharmacists in attendance. 

The CARE Perspectives Conference Report from CHC 2016 and the lunch symposia provides a summary of the most compelling stories and news presented at this event, and provides Canadian perspectives from the CARE Hematology Faculty. 

 


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CHC 2016 Symposia

This year, three symposia were held at this event, focused in Follicular Lymphoma, Complement Disorders, and Supportive Care. We were pleased to welcome a dynamic faculty of Canadian and International KOL’s who provided cutting-edge presentations on these topics of interest.

This supplement to the CARE Perspectives: CHC 2016 provides a summary of these symposia.

CARE Perspectives on ASCO & EHA 2016

Members of the CARE Hematology Faculty recently attended the ASCO & EHA 2016 conferences held in Chicago, Illinois (June 3-7) and Copenhagen, Denmark (June 9-12). CARE was pleased to host the annual resident education meeting in conjunction with ASCO. This meeting brought together a pan-Canadian Faculty of KOLs to showcase news and developments in hematology. Presentations featured cutting edge content with discussion on relevant cases and treatment strategies. CARE at ASCO was attended by over 50 Canadian oncology professionals. Attendees included academic specialists, trainees and residents.

The content that follows is written in the language in which it was presented. The following content is drawn from the abstracts at ASCO and EHA 2016, as well as the presentation made at the CARE at ASCO 2016 meeting by Dr. John Kuruvilla. This report is augmented with content and perspectives from the CARE Hematology Faculty.

CARE Hematology Faculty Who Have Contributed to This Report:

John Kuruvilla, MD
Princess Margaret Cancer Centre

David MacDonald, MD
Dalhousie University

 

Perspectives de CARE: CCH-QC 2016

Rapport de la conférence CARE sur l’hématologie – Québec

Le programme de CARE (Communauté. Académique. Recherche. Éducation) est fier d’avoir complété cette première Conférence CARE sur l'hématologie au Québec (CCH-QC 2016), tenue le 15 avril à Montréal.

Les présentateurs chevronnés provenaient de plusieurs institutions d’enseignement et de recherches du Québec. Des sujets à la fine pointe de l’actualité, relatifs au domaine de l'hématologie, dont le lymphome, la leucémie, les troubles myéloprolifératifs, la dyscrasie plasmocytaire et des troubles bénins rares, ont été présentés.

Ce rapport résume ces présentations données par des spécialistes québécois de premier plan en hématologie. Les présidents de conférence étaient Dr. Denis-Claude Roy et Dr. Luigina Mollica, tous deux de l’Hôpital Maisonneuve-Rosemont (HMR).

La conférence CCH-QC a été préparée par le Comité académique de CARE sur l'hématologie en collaboration avec CellCAN.

Le rapport a été initialement écrit en français. Les tableaux et figures ont été insérés dans la langue choisie par chaque présentateur. 

Présidents de la conférence :

Denis-Claude Roy, MD
Hôpital Maisonneuve-Rosemont

Luigina Mollica, MD
Hôpital Maisonneuve-Rosemont

 

CARE Perspectives CCOLD 2016

Conference Report on Multiple Myeloma and Lymphoproliferative Disorders

Highlights from CCOLD 2016

Members of the CARE Hematology Faculty recently presented at the CCOLD 2016 conference held in Banff, Alberta from March 18-20. This version of CARE Perspectives provides a summary of the presentations on multiple myeloma and lymphoproliferative disorders. 

CARE Hematology Faculty who have contributed to this report:

Kevin Song, MD - BC Cancer Agency
Christopher Venner, MD - Cross Cancer Institute

 

HEMA-TIMES: Paroxysmal Nocturnal Hemoglobinuria Needs Assessment Results

Research led by Dr. Christopher Patriquin and Dr. Loree Larratt

Paroxysmal nocturnal hemoglobinuria (PNH) is an ultra-rare, and under-recognized complement-mediated disease. Because of its rarity, it is not well understood. In order to understand both current perception and knowledge of PNH with hematologists, a needs assessment was conducted. The research is being led by Dr. Christopher Patriquin (McMaster University, The Canadian PNH Network) and Dr. Loree Larratt (University of Alberta, The Canadian PNH Network). 

This needs assessment was distributed by mail and electronically to upwards of 400 Canadian hematologists working in academic teaching centres and/or community practices. The response rate to this needs assessment is 19% (n=77). What follows is an overview of the key takeaways from the needs assessment, along with the response data. 

 

Hematology Year in Review 2015

There were a number of exciting developments in Hematology this year. The Hematology Year in Review 2015 is an interactive report that covers some of the most exciting stories in the field of hematology throughout 2015. An overview of programs that different CARE faculties have developed in 2015 and upcoming conferences in 2016 have also been highlighted in this report.

 


CARE Perspectives ASH 2015

Members of the CARE Hematology Faculty recently attended the American Society of Hematology (ASH) 2015 conference held in Orlando, Florida from December 5-8. The 10th annual CARE at ASH meeting was held on Friday, December 4th and was attended by upwards of 85 trainees and specialists in the community of practice. Leading Canadian specialists spoke on a number of exciting topics in the field of hematology. 

The CARE Perspectives ASH Report provides:

  • A summary of the most compelling stories and news presented at this annual event 
  • Expert perspectives from the CARE Hematology Faculty
  • Supportive CARE considerations 
 
 


CARE Perspectives CHC 2015

CARE Education is pleased to have successfully completed the 5th annual Canadian Hematology Conference (CHC 2015), held on October 2-3 in Toronto, Ontario. 

This two day conference brings together a pan-Canadian and international Faculty of KOLs to showcase news and developments in hematological malignancies. Presentations featured cutting edge content with discussion on relevant cases and treatment strategies.

CHC 2015 is the largest multidisciplinary hematology focused meeting in Canada, attended by over 150 Canadian hematology professionals. Attendees included academic and community specialists, residents, nurses and pharmacists with an interest in hematology.

The CARE Perspectives Conference Report from CHC 2015 provides a summary of content presented by leading Canadian specialists as well as several International hematologists at the event, chaired by Drs. John Kuruvilla & Peter Anglin. 

Below is a link to the full report:

click here for the full report

click here for the full report

 


CARE Perspectives IWCLL 2015

Members of the CARE Hematology Faculty recently attended the IWCLL 2015 conference held in Sydney, Australia (September 7-9).

The CARE Perspectives Conference Report from IWCLL 2015 provides a summary of the most compelling stories and news presented at this event, and is augmented with additional perspective from the CARE Hematology Faculty. 

CLICK HERE TO VIEW THE FULL REPORT

CLICK HERE TO VIEW THE FULL REPORT

 

CARE Perspectives IMW 2015

Members of the CARE Hematology Faculty recently attended the 2015 International Myeloma Workshop (IMW) September 23-26 in Rome, Italy.

The CARE Perspectives Conference Report from IMW provides a summary of the most compelling stories and news presented at this event, and is augmented with additional perspectives from the CARE Hematology Faculty. 

Below is a link to the full report:

CLICK HERE TO VIEW THE FULL REPORT

CLICK HERE TO VIEW THE FULL REPORT

 

CARE Perspectives EHA 2015

Click here to view the full CARE Perspectives EHA 2015 Conference Report. 

Click here to view the full CARE Perspectives EHA 2015 Conference Report. 

Members of the CARE Hematology Faculty recently attended the European Hematology Association (EHA) 2015 conference held in Vienna, Austria (June 11-14).

The CARE Perspectives Conference Report from EHA provides a summary of the most compelling stories and news presented at this event, and is augmented with additional perspectives from the CARE Hematology Faculty. 

Below is a link to the full report:

Click here for the full report.

Click here for the full report.

 

PMCC Multiple Myeloma Day: Update on Multiple Myeloma

Click here to view the full PMCC Multiple Myeloma Day: Update on Multiple Myeloma.

Click here to view the full PMCC Multiple Myeloma Day: Update on Multiple Myeloma.

Princess Margaret Cancer Centre (PMCC) ran its annual PMCC-Multiple Myeloma day meeting on June 19th, 2015. This meeting was attended by leading myeloma specialists, allied health care providers, and pharmacists. Content focused on a number of areas of interest in multiple myeloma, such as relapsed myeloma, post-transplant strategies, and how to personalize myeloma treatment. These are the key topics that are summarized throughout this document.

The content that follows is written in the language in which it was presented. Content is adapted from select presentations and round table discussion from PMCC-MM Day, and is augmented with content and perspectives from the CARE Hematology Faculty. 

Below is a link to the full update as well as a supplementary publication:

Click here for the full update. 

Click here for the full update. 

Click here to read the full CARE Perspectives ICML 2015 Conference Report.

Click here to read the full CARE Perspectives ICML 2015 Conference Report.

 

CARE Perspectives ICML 2015

Click here to read the full CARE Perspectives ICML 2015 Conference Report. 

Click here to read the full CARE Perspectives ICML 2015 Conference Report. 

Members of the CARE Hematology Faculty recently attended the International Conference on Malignant Lymphoma (ICML) held in Lugano, Switzerland (June 17-20). This meeting was attended by 3,000 specialists including hematologists, clinical oncologists, radio- oncologists, paediatricians, pathologists and leading researchers involved in the study and treatment of lymphoid neoplasms.

The CARE Perspectives Conference Report from ICML provides a summary of the most compelling stories and news presented at this event, and is augmented with additional perspectives from the CARE Hematology Faculty. 

Below is a link to the full report as well as a supplementary publication:

Click here for the full report.

Click here for the full report.

Click here to read the full PMCC Multiple Myeloma Day: Update on Multiple Myeloma. 

Click here to read the full PMCC Multiple Myeloma Day: Update on Multiple Myeloma. 

 

CARE Perspectives ASCO Hematology 2015

Click here to view the CARE Perspectives ASCO 2015 hematology Conference Report. 

Click here to view the CARE Perspectives ASCO 2015 hematology Conference Report. 

Members of the CARE (Community. Academic. Research. Education) Oncology and Hematology Faculties recently met at the ASCO 2015 conference held in Chicago from May 29 – June 2. The CARE Resident and Trainee Education meeting was held on May 29th (8:00 am - 1:00 pm). At this meeting CARE Faculty members presented on a number of key topics in oncology, including hematology. The CARE Hematology Faculty then held a separate breakout session after the main meeting that took a deeper look at themes in hematology-oncology. The focus of their discussion was on indolent non-Hodgkin’s lymphoma, chronic lymphocytic leukemia, multiple myeloma, and basic science for antibody drug conjugates. Additionally, due to the exciting news surrounding novel agents in the field of hematology, supportive care considerations for better patient symptom management were addressed at ASCO. This report covers some of the most important story lines in supportive care from ASCO.

The CARE Perspectives Conference Report from ASCO 2015 provides a summary of the most compelling stories and news presented at this event, and is augmented with additional perspectives from the CARE Hematology Faculty. 

Below is a link to the full report:

Click here for the full report.

Click here for the full report.

 

Hema-Times: Understanding the Mechanisms of Action of Multiple Myeloma Therapies and their Clinical Implications

Hema-Times: Understanding the Mechanisms of Action of Multiple Myeloma Therapies and their Clinical Implications

Multiple myeloma (MM) is a plasma cell malignancy based in the bone marrow, in which standard treatments have historically included corticosteroids (e.g. dexamethasone and prednisone) and cytotoxic drugs (e.g. melphalan, vincristine, cyclophosphamide, and doxorubicin). However, the treatment paradigm is shifting away from classical chemotherapy to therapies that more directly target the unique plasma cell biology. This may be either through pathways unique to the plasma cell itself or the tumour microenvironment upon which they are dependent. Significant improvements in overall survival and remission duration in multiple myeloma (MM) are largely due to the advent of novel therapeutic agents, including proteasome inhibitors (PIs) and immunomodulatory drugs (IMiDs). Newer agents, including those that affect the epigenome, and antibody-based therapies that directly target the plasma cell are also coming into play. As the therapeutic landscape widens, it will be important to study these agents and their mechanisms of action (MoA).

This paper will focus on the MoA of existing and new agents, in order to promote a better understanding of how they work, and what their implications are in the Canadian clinical setting. 

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CARE Perspectives CCOLD 2015

Members of the CARE Hematology Faculty recently met at the CCOLD 2015 (Canadian Conference on Lymphoproliferative Disorders) conference held in Banff, AB on March 20-22, 2015. A warm thanks to Dr. Wendy Lam and the planning committee for organizing this meeting.

The CARE Perspectives CCOLD 2015 conference report provides a summary of the most compelling stories and news presented at this event, and is augmented with additional perspective from the CARE Hematology Faculty. The results of a recent CARE needs assessment focused on subsequent entry biologics are included in this report. 

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Subsequent Entry Biologics Needs Assessment Results

The advent of biologics has improved patient outcomes in terms of patient survival as well as drug delivery. With many of Canada’s top selling biologic molecules facing patent expiration before 2020, a greater number of more affordable subsequent entry biologics (SEBs) will compete with ‘branded’ biologics. SEBs are ‘biologics that are similar to, and enter the market subsequent to, an approved innovator biologic’. These SEBs are of interest, yet present challenges. Certain issues and questions surrounding the differences between SEBs and biologics (eg. cost, manufacturing, approval processes, etc.), need to be considered as more SEBs are developed and become available. This needs assessment focuses on some of these issues. 

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CARE Perspectives ASH 2014

Members of the CARE Hematology Faculty attended the ASH 2014 conference held in San Francisco, California from December 6-9th 2014. The CARE at ASH education event was held with trainees and community hematologists from across Canada and covered various topics in hematology. This report provides an overview of the key abstracts and sessions from ASH discussed at this meeting, with Canadian perspectives provided by Faculty.

The report content that follows is drawn from ASH 2014 and is augmented with the CARE Hematology Faculty Canadian perspective and commentary. Full abstract content can be found on the ASH website at: ash.confex.com/ash/2014/webprogram/start.html

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CARE Perspectives CHC 2014

CARE (Community Academic Research Education) has successfully completed its fourth year of hosting the Canadian Hematology Conference (CHC), previously known as TLC, (Toronto Lymphoproliferative Conference). There was great attendance, made up of hematologist-oncologists from academic and community centres, supportive care repre- sentatives and pharmacists. Key news and developments were discussed in a number of different hematological malignancies. 

To show the comprehensive and multidisciplinary nature of CHC 2014, an abridged scientific programme and featured sessions are reviewed in the pages that follow. Chairs and presenters of each session are identified at the beginning of each section. 

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