Best Abstract #3: Vitamin D Status and Inflammation in Cancer and Other Diseases P. Autier
Background: Several observational studies have identified an apparent association between 25-hydroxy-vitamin D levels and various disease states including poor bone health and malignancy. However, what is not known is whether this is apparent effect is correlative or modifiable.
Methods: The authors performed an analysis of systematic reviews, randomized trials and prospective cohort studies published up to December 2012 to determine if increasing vitamin D levels might be associated with a reduction in the risk of multiple health conditions including malignancy.
Results: 273 trials involving 1.2 million adult patients were identified. High vitamin D levels were associated with a reduction in the likelihood of death from only colorectal cancer although there was a trend toward improved outcomes for patients with both pancreas and prostate cancers. Vitamin D levels also appeared to be associated with aggressiveness of disease. Lower levels of vitamin D were associated with conditions leading to systemic inflammation but, interestingly, supplementing vitamin D did not appear to be associated with a reduction in the inflammatory process or a reduction in the incidence or aggressiveness of malignancy.
Conclusions: Vitamin D status appears to represent a consequence rather than a cause of poor health and is likely due to underlying systemic inflammatory processes.