Rheumatology Primer on Biosimilars

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CARE™ Primer on Biosimilars

The primer offers information on biologics and biosimilars, with a focus on the basic science, regulatory pathways, clinical data and implications, as well as legal perspectives. 

    • Biologic therapy has revolutionized the treatment of many rheumatological disorders, and drastically improved patient outcomes.
    • Many biologic therapies used in rheumatology have gone, or are going off patent, and competitive biosimilars are being introduced. 
    • Biosimilars not only have implications for specialty fields, but also for the general delivery of health care in Canada. 

    What follows is a primer on biologics and biosimilars, updated to reflect a rheumatological perspective. This educational report was created in conjunction with CARE™ Faculty Member Dr. Philip Baer (Ontario Medical Association), and details the basic science, management and regulatory pathways, legal perspectives and recent clinical data on biosimilars. This report is also informed by various CARE™ faculties and recent biosimilar news.

    This Rheumatology Biosimilars Primer is written as of July 2018 and is subject to update and refinement. It is based upon a multi-disciplinary CARE™ Primer on Biosimilars (produced Fall 2017). For more information on CARE™ visit CAREeducation.ca. To access the comprehensive primer visit: http://www.CAREeducation.ca/primer.


    Contributing Authors

    Philip A. Baer, MDCM, FRCPC, FACR
    CARE™ Rheumatology Faculty
    Ontario Medical Association

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    Scott Edwards, B.Sc., Pharm
    Dr. H. Bliss Murphy Cancer Centre

    Rob Laister, PhD
    Princess Margaret Cancer Centre

    Jason Thomas, RPh, B.Sc., Pharm
    Juravinski Cancer Centre 

    CARE Perspectives on EULAR 2017

    Members of the CARE Rheumatology Faculty recently attended the European League Against Rheumatism (EULAR) 2017 conference held in Madrid, Spain from June 14th -17th.

    The CARE Perspectives Conference Report from EULAR 2017 provides a summary of compelling trial data, augmented with perspectives from the CARE Rheumatology Faculty. 

    This report emphasizes news from a Canadian perspective, Canadian content is highlighted accordingly.  

    CARE Faculty who have contributed to this report:

    Philip Baer, MD
    Ontario Medical Association

    Denis Choquette, MD
    Centre hospitalier de l'Université de Montréal

    Janet Pope, MD
    Western University

    CARE Rheumatology Guiding Principles on Biosimilars

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    This initiative is led by:
    Drs. Philip Baer, Vinod Chandran & Denis Choquette

    The CARE Faculty has been looking at the impact of biosimilars since 2015, given the significance of this topic across both chronic and disease entities. Select CARE Rheumatology Faculty members have consolidated the following guiding principles based on the collective discussion from past CARE Education initiatives that explored the anticipated impact that the introduction of biosimilars will have in Canada.

    Biosimilars have been a topic of interest for various CARE™ Faculties for several years now. To gauge levels of understanding along with perceptions and opinions on the impact that biosimilars will have on the Canadian landscape, a number of CARE faculties conducted needs assessments with their peers. Between 2014-2016, needs assessments were directed at specialists in gastroenterology, rheumatology, oncology, and hematology.

    The aim of developing these principles is to provide Canadian health care providers with an overarching view of the positions from the CARE Faculties, which in turn may help inform their treatment decisions.

     

    CARE Perspectives on ACR 2016

    Highlights from ACR 2016

    Members of the CARE Rheumatology Faculty recently attended the ACR 2016 conference held in San Francisco from November 6-11.

    The CARE Perspectives Conference Report from ACR 2016 provides a summary of the most compelling stories and news presented at this event, and is augmented with additional perspective from the CARE Rheumatology Faculty. 

    The content that follows is written in the language in which it was presented. The following content is adapted from the presentations made at the ACR 2016 meeting, and is augmented with content and perspective from the CARE Rheumatology Faculty.

    CARE Rheumatology Faculty who have contributed to this report:

    Vinod Chandran, MD
    Toronto Western Hospital    

    Denis Choquette, MD
    Centre hospitalier de l'Université de Montréal

    Janet Pope, MD
    Western University

    CARE Perspectives on EULAR 2016

    Highlights from EULAR 2016

    Members of the CARE Rheumatology Faculty recently attended the European League Against Rheumatism (EULAR) 2016 conference held in London, England from June 8-11.

    The CARE Perspectives Conference Report from EULAR 2016 provides a summary of the most compelling stories and news presented at this event, and is augmented with additional perspectives from the CARE Rheumatology Faculty. 

    The content that follows is written in the language in which it was presented and is adapted from the abstracts from the EULAR 2016 meeting. Perspectives from the CARE Rheumatology Faculty are also included.

    CARE Rheumatology Faculty who have contributed to this report:

    Vinod Chandran, MD, PhD
    Toronto Western Hospital    

    Denis Choquette, MD
    Centre hospitalier de l'Université de Montréal

    Janet Pope, MD
    Western University

     

    CARE Perspectives on ACR 2015

    Highlights from ACR 2015

    Members of the CARE Rheumatology Faculty recently attended the ACR 2015 conference held in San Francisco from November 6-11.

    The CARE Perspectives Conference Report from ACR 2015 provides a summary of the most compelling stories and news presented at this event, and is augmented with additional perspective from the CARE Rheumatology Faculty. 

    The content that follows is written in the language in which it was presented. The following content is adapted from the presentations made at the ACR 2015 meeting, and is augmented with content and perspective from the CARE Rheumatology Faculty.

    CARE Rheumatology Faculty who have contributed to this report:

    Vinod Chandran, MD
    Toronto Western Hospital    

    Denis Choquette, MD
    Centre hospitalier de l'Université de Montréal

    Janet Pope, MD
    Western University